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  "Title": "A Family of Beta Mixture Models for Clustering Beta-Valued DNA\nMethylation Data",
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  "Authors@R": "c(person(\"Koyel\", \"Majumdar\",email = \"koyel.majumdar@ucdconnect.ie\", role = c(\"aut\", \"cre\"), comment = c(ORCID = \"0000-0003-4692-9002\")),\nperson(\"Romina\",\"Silva\",email=\"romina.silva@ucdconnect.ie\",role=\"aut\"),\nperson(\"Antoinette Sabrina\",\"Perry\",email=\"antoinette.perry@ucd.ie\",role=\"aut\"),\nperson(\"Ronald William\",\"Watson\",email=\"william.watson@ucd.ie\",role=\"aut\"),\nperson(\"Andrea\",\"Rau\",email=\"andrea.rau@inrae.fr\",role=\"aut\",comment = c(ORCID = \"0000-0001-6469-488X\")),\nperson(\"Florence\",\"Jaffrezic\",email=\"florence.jaffrezic@inrae.fr\",role=\"aut\"),\nperson(\"Thomas Brendan\", \"Murphy\",email = \"brendan.murphy@ucd.ie\", role = c(\"aut\"), comment = c(ORCID = \"0000-0002-5668-7046\")),\nperson(\"Isobel Claire\", \"Gormley\",email = \"claire.gormley@ucd.ie\", role = c(\"aut\"), comment = c(ORCID = \"0000-0001-7713-681X\")))",
  "Description": "A family of novel beta mixture models (BMMs) has been\ndeveloped by Majumdar et al. (2022)\n<doi:10.48550/arXiv.2211.01938> to appositely model the\nbeta-valued cytosine-guanine dinucleotide (CpG) sites, to\nobjectively identify methylation state thresholds and to\nidentify the differentially methylated CpG (DMC) sites using a\nmodel-based clustering approach. The family of beta mixture\nmodels employs different parameter constraints applicable to\ndifferent study settings. The EM algorithm is used for\nparameter estimation, with a novel approximation during the\nM-step providing tractability and ensuring computational\nfeasibility.",
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  "Repository": "https://koyelucd.r-universe.dev",
  "Date/Publication": "2024-09-24 09:22:46 UTC",
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  "Packaged": {
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      "topics": [
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      "title": "betaclust: a family of beta mixture models for beta-valued DNA methylation data",
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